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European Group for the Study of Insulin Resistance (EGIR)

Unlike direct GH therapy, Sermorelin rarely causes significant fluid retention, carpal tunnel syndrome, joint pain, or severe insulin resistance that can complicate GH replacement, though mild versions of these effects are theoretically possible if GH stimulation is excessive

doi: 10.1038/nature23272

GHRH + GHRP synergy and dual-pathway GH stimulation

A subsequent larger RCT (n=72) confirmed these findings, showing improvements in gait speed, grip strength, exercise capacity, waist circumference, and systolic blood pressure (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]